John Jokroye109

John Jokroye109

Posted on 06/20/2017

Photo taken on June 20, 2017



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BOTOX® Cosmetic is a purified protein complex derived from the bacterium Clostridium botulinum that smoothes the muscles by blocking nerve impulses. BOTOX® Cosmetic blocks the release of acetylcholine at the neuromuscular junction thereby preventing the contraction of muscles.

In detail, BOTOX® binds to the nerve terminal, internalizes by receptor mediated endocytosis, cleaves a cytoplasmic protein called SNAP-25 and blocks the fusion of the vesicles containing acetylcholine with the nerve membrane. After time, nerve end plate expands and collateral terminal sprouts appear. Once the parent nerve terminal regains function, the collateral terminals retract.